Saliva DNA test could determine future health
by Nazan Saatci ve Dostlari on Thursday, september 20, 2012 at 2:33pm ·
Saliva DNA test could determine future health
Quick, low-cost test being developed at Edinburgh University could determine whether a person is prone to disease
A new DNA test uses saliva to determine whether someone is prone to developing a life-threatening illness
A fast, low-cost DNA test which can determine a person's chances of developing certain inherited diseases could soon be a reality, scientists said today.
A drop of saliva will be enough to allow medics to pinpoint variations in patients' genetic code in a test being formulated by scientists at Edinburgh University.
Tiny differences or omissions at critical points in the DNA chain can determine whether a person is healthy, prone to disease, or has a life-threatening condition such as cystic fibrosis.
The method, based on chemical analysis, is cheaper and promises prompter results than conventional DNA testing because it does away with the need for expensive enzymes, researchers said.Dr Juan Diaz-Mochon, of the University's School of Chemistry, said: "This technology offers a speedy, cost-efficient alternative to existing methods of DNA analysis.
"The market for DNA testing is quickly expanding as it becomes more affordable. Our method could help reach the goal of complete genome analysis in a few hours for less than $1,000 (£637)."
Professor Mark Bradley, who also took part in the study, added: "We plan to test the technology further, extend our collaborations with leading researchers and companies in the DNA sequencing field and establish our first commercial operations within the next six months."
The study, published in the journal Angewandte Chemie, was funded by Scottish Enterprise.
New saliva test 'can detect various cancers'
The test detected 99 percent of pancreatic cancer cases, 95 percent of breast cancer and 80 percent of oral cancer cases.
By Agence France-PresseTue, Jun 29 2010 at 6:15 AM EST
LIFE-SAVING TEST: Early detection could save many lives — survival rates of pancreatic and oral cancer are especially low because they don't show clear symptoms in early stages. (Photo: ZUMA Press)
Japanese and U.S. universities have jointly developed a medical technique that can quickly detect various cancers using a simple saliva test, researchers said on Tuesday.
Japan's Keio University and University of California, Los Angeles, have developed the technology with which they detected high probabilities of pancreatic cancer, breast cancer and oral cancer.
The researchers analysed saliva samples of 215 people, including cancer patients, and identified 54 substances whose presence can be used to detect the disease, Keio University said in a statement released Monday.
By further analysing the substances, the test detected 99 percent of pancreatic cancer cases, 95 percent of breast cancer and 80 percent of oral cancer cases among those taking part, it said.
The cancer test using the technology would take half a day at the longest, the researchers said.
The new technology can detect up to 500 different substances found in saliva at one time, said professor Tomoyoshi Soga at Keio's Institute for Advanced Biosciences.
He said the technology would make it especially easier to detect pancreatic and oral cancers.
"The survival rates of pancreatic cancer and oral cancer are especially low, because they don't show clear symptoms in early stages, which often delays spotting of the illness," the statement said.
"Saliva can be sampled more easily and casually than blood or stool inspection," said institute head Masaru Tomita in the statement.
"We would like to apply this technology not only to cancer cases but also other illnesses as well," he said.
Copyright 2010 AFP American Edition
Quick, low-cost test being developed at Edinburgh University could determine whether a person is prone to disease
A new DNA test uses saliva to determine whether someone is prone to developing a life-threatening illness
A fast, low-cost DNA test which can determine a person's chances of developing certain inherited diseases could soon be a reality, scientists said today.
A drop of saliva will be enough to allow medics to pinpoint variations in patients' genetic code in a test being formulated by scientists at Edinburgh University.
Tiny differences or omissions at critical points in the DNA chain can determine whether a person is healthy, prone to disease, or has a life-threatening condition such as cystic fibrosis.
The method, based on chemical analysis, is cheaper and promises prompter results than conventional DNA testing because it does away with the need for expensive enzymes, researchers said.Dr Juan Diaz-Mochon, of the University's School of Chemistry, said: "This technology offers a speedy, cost-efficient alternative to existing methods of DNA analysis.
"The market for DNA testing is quickly expanding as it becomes more affordable. Our method could help reach the goal of complete genome analysis in a few hours for less than $1,000 (£637)."
Professor Mark Bradley, who also took part in the study, added: "We plan to test the technology further, extend our collaborations with leading researchers and companies in the DNA sequencing field and establish our first commercial operations within the next six months."
The study, published in the journal Angewandte Chemie, was funded by Scottish Enterprise.
New saliva test 'can detect various cancers'
The test detected 99 percent of pancreatic cancer cases, 95 percent of breast cancer and 80 percent of oral cancer cases.
By Agence France-PresseTue, Jun 29 2010 at 6:15 AM EST
LIFE-SAVING TEST: Early detection could save many lives — survival rates of pancreatic and oral cancer are especially low because they don't show clear symptoms in early stages. (Photo: ZUMA Press)
Japanese and U.S. universities have jointly developed a medical technique that can quickly detect various cancers using a simple saliva test, researchers said on Tuesday.
Japan's Keio University and University of California, Los Angeles, have developed the technology with which they detected high probabilities of pancreatic cancer, breast cancer and oral cancer.
The researchers analysed saliva samples of 215 people, including cancer patients, and identified 54 substances whose presence can be used to detect the disease, Keio University said in a statement released Monday.
By further analysing the substances, the test detected 99 percent of pancreatic cancer cases, 95 percent of breast cancer and 80 percent of oral cancer cases among those taking part, it said.
The cancer test using the technology would take half a day at the longest, the researchers said.
The new technology can detect up to 500 different substances found in saliva at one time, said professor Tomoyoshi Soga at Keio's Institute for Advanced Biosciences.
He said the technology would make it especially easier to detect pancreatic and oral cancers.
"The survival rates of pancreatic cancer and oral cancer are especially low, because they don't show clear symptoms in early stages, which often delays spotting of the illness," the statement said.
"Saliva can be sampled more easily and casually than blood or stool inspection," said institute head Masaru Tomita in the statement.
"We would like to apply this technology not only to cancer cases but also other illnesses as well," he said.
Copyright 2010 AFP American Edition
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